2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-U00121A
    Lintopride hydrochloride 268548-31-8 98%
    Lintopride hydrochloride, a benzamide, is a potent 5HT-4 antagonist with moderate 5HT-3 antagonist properties. Lintopride hydrochloride increases gastric emptying, stimulates antral and duodenal motility and accelerates intestinal transit in animal. Lintopride hydrochloride significantly increases the lower oesophageal sphincter (LOS) basal tone.
    Lintopride hydrochloride
  • HY-U00462S
    D-Mannoheptulose-13C 98%
    D-Mannoheptulose-13C is the 13C labeled D-Mannoheptulose (HY-U00462). D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources.
    D-Mannoheptulose-13C
  • HY-W002852
    3-Amino-3-(p-tolyl)propionic acid 68208-18-4 98%
    3-Amino-3-(p-tolyl) propionic acid (3-Amino-3-(4-methylphenyl) propanoic acid) is a GPR40 agonist. 3-Amino-3-(p-tolyl) propionic acid is used for research on type 2 diabetes, obesity, metabolic syndrome and lipid disorders.
    3-Amino-3-(p-tolyl)propionic acid
  • HY-W008940
    Cytidine 5'-diphosphate disodium salt 54394-90-0 98.03%
    Cytidine 5'-diphosphate (Cytidine) disodium salt is a nucleoside diphosphate that acts as a carrier for phosphorylcholine, diacylglycerol, and other molecules during phospholipid synthesis.
    Cytidine 5'-diphosphate disodium salt
  • HY-W009458
    3-Indoxyl phosphate sodium 3318-43-2 98%
    3-Indoxyl phosphate (3-IP) is a chromogenic and electrochemical substrate for alkaline phosphatase. Upon enzymatic cleavage by alkaline phosphatase, 3-indoxyl is released and subsequently oxidized to produce water-insoluble indigo, which can be quantified by colorimetric detection at 660 nm as a measure of alkaline phosphatase activity. 3-Indoxyl phosphate can also be converted to water-soluble leucoindigo by reduction of indigo in alkaline solution by sodium dithionite, which can be quantified by colorimetric detection at 415 nm or voltametric detection as a measure of alkaline phosphatase activity.2 3-Indoxyl phosphate has been used in ELISAs.
    3-Indoxyl phosphate sodium
  • HY-W010902
    Calcium fructose diphosphate 6055-82-9 98%
    Calcium fructose diphosphate (Dicalcium 1,6-di-O-phosphonato-L-tagatose) is a crucial intermediate in the glycolysis process and is closely related to ATP synthesis. Calcium fructose diphosphate can be used to regulate calcium and phosphorus balance, protect myocardial tissue from ischemia/reperfusion injury, counteract the effects of alcohol, and serve as a safer source of phosphate in parenteral nutrition.
    Calcium fructose diphosphate
  • HY-W011269
    Eicosapentaenoic Acid sodium 73167-03-0
    Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation.
    Eicosapentaenoic Acid sodium
  • HY-W012077
    3'-NH2-ddT 52450-18-7 98%
    3'-NH2-ddT (3′-Amino-2′,3′-dideoxythymidine) is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-NH2-ddT
  • HY-W012856
    3-Ethyltoluene 620-14-4 98%
    3-Ethyltoluene (3-Methylethylbenzene) is an isomer of Ethyltoluenes. 3-Ethyltoluene inhibits cell survival and proliferation and increases ROS production. 3-Ethyltoluene upregulates cellular inflammatory gene expression. 3-Ethyltoluene induces cell fibrosis with increased level of AST, FGF-23, Cyt-7 p21, TGFβ, TIMP2, and MMP2. 3-Ethyltoluene can be used for liver diseases such as NAFLD research.
    3-Ethyltoluene
  • HY-W013803
    Xanthosine dihydrate 5968-90-1 98%
    Xanthosine dihydrate is a nucleoside derived from xanthine and ribose. Xanthosine dihydrate activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine dihydrate promotes cell proliferation and regulates blood glucose metabolism. Xanthosine dihydrate increases milk production in cows and goats. Xanthosine dihydrate is used in mammary stem cell and type 2 diabetes research.
    Xanthosine dihydrate
  • HY-W015672
    2-Methylquinoxaline 7251-61-8
    2-Methylquinoxaline is a detection marker of Methylglyoxal (HY-106634) and can be used for quantitative Methylglyoxal. 2-Methylquinoxaline can be used for the researches of type 2 diabetes and Alzheimer's disease.
    2-Methylquinoxaline
  • HY-W015697
    3-Methylquinoline 612-58-8 ≥98.0%
    3-Methylquinoline is a selective cytochrome P450 (CYP1A2) inhibitor with an IC50 of 13 μM. 3-Methylquinoline can reduce the metabolic clearance of CYP1A2 substrate drugs. 3-Methylquinoline can inhibit the activation of carcinogenic precursors.
    3-Methylquinoline
  • HY-W018339
    2-Aminopyrimidin-5-ol 143489-45-6 99.28%
    2-Aminopyrimidin-5-ol is an endogenous metabolite.
    2-Aminopyrimidin-5-ol
  • HY-W019780
    Bromodichloromethane 75-27-4 98%
    Bromodichloromethane (Dichlorobromomethane) is a type of trihalomethane, commonly found in chlorinated drinking water for disinfection, and is a disinfection by-product. The bromination of bromodichloromethane can cause the formation of mutagenic intermediates through the transformation mediated by glutathione S-transferase (GST). Bromodichloromethane inhibits the differentiation of human placental trophoblast cells and reduces the secretion of chorionic gonadotropin (CG). Bromodichloromethane has potential reproductive toxicity and carcinogenicity.
    Bromodichloromethane
  • HY-W019781
    Biotinylated sphingosine 752987-57-8 98%
    Biotinylated sphingosine (Biotinyl-Sph) is a substrate of sphingosine kinase that can b used to detect the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2.
    Biotinylated sphingosine
  • HY-W020788
    Benoxacor 98730-04-2 99.39%
    Benoxacor (CGA 154281) is a herbicide safener and xenobiotic metabolism regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity.
    Benoxacor
  • HY-W031230
    N4-Acetylsulfamerazine 127-73-1 98%
    N4-Acetylsulfamerazine is a sulfonamides derivative.
    N4-Acetylsulfamerazine
  • HY-W036553
    6-Hydroxypyridin-2(1H)-one hydrochloride 10357-84-3 98.73%
    6-Hydroxypyridin-2(1H)-one hydrochloride is an endogenous metabolite.
    6-Hydroxypyridin-2(1H)-one hydrochloride
  • HY-W037817
    Dimethyl L-glutamate 6525-53-7 98%
    Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the KATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism.
    Dimethyl L-glutamate
  • HY-W037980
    Succinamic acid 638-32-4 98%
    Succinamic acid is a weak inhibitor for human LL-xylose reductase with an IC50 of 1.45 mM. Succinamic acid can be used as a linker for synthesis of CQ-16 (HY-169336).
    Succinamic acid
Cat. No. Product Name / Synonyms Application Reactivity